T cell receptors play a crucial role in maintaining skin homeostasis. These cells extend dendrites to the basal and corneum layers of the epidermis. A long with langerhan cells, they form a large part of the immunity within the layers of the epidermis.
Here are six things you need to know about epidermal T cells.
- T cells mature in the thymus gland and are an integral part to the immune system.
- The thymus gland is large during childhood. Though as we age the thymus gland reduces it`s size. Stress also affects the thymus gland and it becomes smaller.
- When we have these changes to the thymus gland there is less maturation of T cells. This affects the immune system and it does not have the same strength.
- An epidermal T cell has a dendritic shape though once they activated, they change their shape and become round. They then secrete a range of cytokines, chemokines and growth factors
- This activation increases keratinocyte proliferation and recruitment of infiltrating leukocytes. This is an important factor as it increase wound repair as well as the immunity of the skin.
- T cells are an important part of the epidermis immune system, they regulate the skin`s inflammatory responses and recognize stressed keratinocyte cells.
Epidermal T cells form a critical part to the skin`s immune system, they have the ability to modulate immune responses that are initiated and expressed in skin. They play and important role in maintaining the immunologic integrity of the skin.
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Yours in Skin